Research Summary  

Our laboratory is interested in determining the molecular mechanisms that regulate stem cell self-renewal, differentiation, and de-differentiation and how these mechanisms become deregulated in cancer. When starting the lab in 2006, we largely focused on the role of post-transcriptional regulators including microRNAs (miRNAs) and RNA binding proteins (RBPs). However, in past five years, we have also added a focus on epigenetic mechanism associated with enhancer control. In addition, we have developed a strong interest in exosomes both as biomarkers and regulators of cancer progression.

 

Latest News

screenshot of NYTimes page
April 04, 2019

Please check out these articles for various perspectives on our work.  

April 04, 2019

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory